Protective Activity of Silipide on Liver Damage in Rodents

Protective activity of silipide on liver damage in rodents.

The activity of silipide, a silybin-phosphatidylcholine complex (IdB 1016), was tested in different models of liver damage in rodents. After oral administration, silipide exhibited a significant and dose-related protective effect against the hepatotoxicity induced by CCl4, praseodymium, ethanol and galactosamine. The ED50 values for inhibition of the rise in ASAT and ALAT levels caused by CCl4 ...

Protective Effect of Low Dose Melatonin on Radiation-Induced Damage to Rat Liver

Background: Melatonin is a free radical scavenger. It has also antioxidant effects through its stimulatory actions on antioxidant system. Objective: We conducted this study to examine the effect of different oral doses of melatonin on liver tissue. Methods: We used 42 rats—6 rats in each group. Group I served as the control group; group II rats were pretreated with only melatonin; group III w...

Impact of Propionic Acid on Liver Damage in Rats

Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific ...

Protective Effect of Silymarin on Liver Damage by Xenobiotics

Hepatoprotective activity of aerial parts of Otostegia persica against carbon tetrachloride-induced liver damage in rats

Objective: To evaluate the hepatoprotective properties of Otostegia persica (O. persica) ethanol extract on carbon tetrachlo‌‌ride-induced liver damage in rats. Materials and Methods: Fifty adult male Wistar rats were randomly divided into five groups. Group I served as normal control and was given only olive oil intraperitoneally (i.p.). Group II, III, IV, and V were administered CCl4 mixed wi...